Genetics, Vol. 179, 723-726, May 2008, Copyright © 2008
doi:10.1534/genetics.108.088146

Identification of New Quantitative Trait Loci (Other Than the PRNP Gene) Modulating the Scrapie Incubation Period in Sheep

C. R. Moreno*,1, G. M. Cosseddu{dagger},{ddagger}, L. Schibler{dagger}, A. Roig{dagger}, K. Moazami-Goudarzi{dagger}, O. Andreoletti§, F. Eychenne**, D. Lajous*, F. Schelcher§, E. P. Cribiu{dagger}, P. Laurent{dagger}, D. Vaiman{dagger},{dagger}{dagger},{ddagger}{ddagger},§§ and J. M. Elsen*

* INRA, UR 631 Amélioration Génétique des Animaux, BP52627, 31326 Castanet-Tolosan, France, {dagger} INRA, UR 339 Génétique Biochimique et Cytogénétique, 78352 Jouy-en-Josas, France, § INRA-ENV Toulouse, Interaction Hôtes Agents Pathogènes, 31076 Toulouse, France, ** INRA, UE65 Domaine Expérimental de Langlade, Pompertuzat, 31450 Montgiscard, France, {ddagger} Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy, {dagger}{dagger} INSERM, U567 Institut Cochin, Team 21, 75014 Paris, France, {ddagger}{ddagger} CNRS UMR810424, 75014 Paris, France and §§ Université Paris Descartes, Faculté de Médecine Cochin-Port-Royal, 75014 Paris, France

1 Corresponding author: SAGA, INRA, BP52627, 31326 Castanet-Tolosan Cedex, France.
E-mail: moreno{at}toulouse.inra.fr

Although susceptibility to scrapie is largely controlled by the PRNP gene, we have searched for additional genomic regions that affect scrapie incubation time in sheep, using two half-sib families with a susceptible PRNP genotype and naturally infected by scrapie. Quantitative trait loci were detected on OAR6 and OAR18.