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Ludwig-Maximilians University, Biocenter, 82152 Planegg, Germany
1 Corresponding author: Mathematical Institute, Albert-Ludwigs University, Eckerstrasse 1, D-79104 Freiburg, Germany.
E-mail: peter.pfaffelhuber{at}stochastik.uni-freiburg.de
between a pair of polymorphic sites. For our analysis we use the approximation of a star-like genealogy at the selected site. The resulting expressions are approximately correct in the limit of large selection coefficients. Using simulations we show that the resulting pattern of linkage disequilibrium is quickly—i.e., in <0.1N generations—destroyed after the fixation of the beneficial allele for moderately distant neutral loci, where N is the diploid population size. Related articles in Genetics:
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