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Genetics, Vol. 179, 291-304, May 2008, Copyright © 2008
doi:10.1534/genetics.107.086520
Saccharomyces cerevisiae Yta7 Regulates Histone Gene Expression
Angeline Gradolatto*,
Richard S. Rogers
,
Heather Lavender*,
Sean D. Taverna
,
C. David Allis,
John D. Aitchison and
Alan J. Tackett*,1
* Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, Institute for Systems Biology, Seattle, Washington 98103 and The Rockefeller University, New York, New York 10065
1 Corresponding author: University of Arkansas for Medical Sciences, 4301 W. Markham St., Slot 516, Little Rock, AR 72205.
E-mail: ajtackett{at}uams.edu
The Saccharomyces cerevisiae Yta7 protein is a component of a nucleosome bound protein complex that maintains distinct transcriptional zones of chromatin. We previously found that one protein copurifying with Yta7 is the yFACT member Spt16. Epistasis analyses revealed a link between Yta7, Spt16, and other previously identified members of the histone regulatory pathway. In concurrence, Yta7 was found to regulate histone gene transcription in a cell-cycle-dependent manner. Association at the histone gene loci appeared to occur through binding of the bromodomain-like region of Yta7 with the N-terminal tail of histone H3. Our work suggests a mechanism in which Yta7 is localized to chromatin to establish regions of transcriptional silencing, and that one facet of this cellular mechanism is to modulate transcription of histone genes.