help button home button Genetics Science
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Genetics, Vol. 178, 2113-2121, April 2008, Copyright © 2008
doi:10.1534/genetics.107.081927

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Google Scholar
Right arrow Articles by Seyfert, A. L.
Right arrow Articles by Lynch, M.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seyfert, A. L.
Right arrow Articles by Lynch, M.

The Rate and Spectrum of Microsatellite Mutation in Caenorhabditis elegans and Daphnia pulex

Amanda L. Seyfert*,1, Melania E. A. Cristescu{dagger}, Linda Frisse{ddagger}, Sarah Schaack*, W. Kelley Thomas§ and Michael Lynch*

* Department of Biology, Indiana University, Bloomington, Indiana 47405, {dagger} Great Lakes Institute for Environmental Research, University of Windsor, Windsor, Ontario N9B 3P4, Canada, {ddagger} National Center for Biotechnology and Information, U. S. National Library of Medicine, Bethesda, Maryland 20894 and § Hubbard Center for Genome Studies, University of New Hampshire, Durham, New Hampshire 03824

1 Corresponding author: Department of Biology, Indiana University, 1001 E. 3rd St., Bloomington, IN 47405.
E-mail: aseyfert{at}indiana.edu

The effective use of microsatellite loci as tools for microevolutionary analysis requires knowledge of the factors influencing the rate and pattern of mutation, much of which is derived from indirect inference from population samples. Interspecific variation in microsatellite stability also provides a glimpse into aspects of phylogenetic constancy of mutational processes. Using long-term series of mutation-accumulation lines, we have obtained direct estimates of the spectrum of microsatellite mutations in two model systems: the nematode Caenorhabditis elegans and the microcrustacean Daphnia pulex. Although the scaling of the mutation rate with the number of tandem repeats is highly consistent across distantly related species, including yeast and human, the per-cell-division mutation rate appears to be elevated in multicellular species. Contrary to the expectations under the stepwise mutation model, most microsatellite mutations in C. elegans and D. pulex involve changes of multiple repeat units, with expansions being much more common than contractions.




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Lynch, W. Sung, K. Morris, N. Coffey, C. R. Landry, E. B. Dopman, W. J. Dickinson, K. Okamoto, S. Kulkarni, D. L. Hartl, et al.
From the Cover: A genome-wide view of the spectrum of spontaneous mutations in yeast
PNAS, July 8, 2008; 105(27): 9272 - 9277.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the Genetics Society of America.