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Originally published as Genetics Published Articles Ahead of Print on February 3, 2008.

Genetics, Vol. 178, 2045-2053, April 2008, Copyright © 2008
doi:10.1534/genetics.107.084566

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Defining Regions and Rearrangements of the Silene latifolia Y Chromosome

R. Bergero*, D. Charlesworth*,1, D. A. Filatov{dagger} and R. C. Moore{ddagger}

* Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 3JT, United Kingdom, {dagger} Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom and {ddagger} Botany Department, Miami University, Oxford, Ohio 45056

1 Corresponding author: Ashworth Laboratories, King's Buildings, West Mains Rd., University of Edinburgh, Edinburgh EH9 3JT, United Kingdom.
E-mail: deborah.charlesworth{at}ed.ac.uk

We combine data from published marker genotyping of three sets of S. latifolia Y chromosome deletion mutants with changed sex phenotypes and add genotypes for several new genic markers to refine the deletion map of the Y chromosome and compare it with the X chromosome genetic map. We conclude that the Y chromosome of this species has been derived through multiple rearrangements of the ancestral gene arrangement and that none of the rearrangements so far detected was involved in stopping X–Y recombination. Different Y genotypes may also differ in their gene content and possibly arrangements, suggesting that mapping the Y-linked sex-determining genes will be difficult, even if many further genic markers are obtained. Even in determining the map of Y chromosome markers to discover all the rearrangements, physical mapping by FISH or other experiments will be essential. Future deletion mapping work should ensure that markers are studied in the parents of deletion mutants and should probably include additional deletions that were not ascertained by causing mutant sex phenotypes.






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