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Genetics, Vol. 178, 589-591, January 2008, Copyright © 2008
doi:10.1534/genetics.107.083642
Differential Regulation of Anaphase Promoting Complex/Cyclosome Substrates by the Spindle Assembly Checkpoint in Saccharomyces cerevisiae
Brice E. Keyes*,
Christopher M. Yellman
and
Daniel J. Burke*,1
* Department of Biochemistry and Molecular Genetics, University of Virginia Medical Center, Charlottesville, Virginia 22908 and Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06511
1 Corresponding author: Department of Biochemistry and Molecular Genetics, University of Virginia Medical Center, 1300 Jefferson Park Ave., Box 800733, Charlottesville, VA 22908.
E-mail: dburke{at}virginia.edu
The anaphase promoting complex (APC) targets proteins for degradation to promote progression through the cell cycle. Here we show that Clb5, an APCCdc20 substrate, is degraded when the spindle checkpoint is active, while other APCCdc20 substrates are stabilized, suggesting that APCCdc20 inhibition by the spindle checkpoint is substrate specific.