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Genetics, Vol. 177, 2525-2530, December 2007, Copyright © 2007
doi:10.1534/genetics.107.080408

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Synthetic Lethal Interactions Identify Phenotypic "Interologs" of the Spindle Assembly Checkpoint Components

Maja Tarailo, Sanja Tarailo and Ann M. Rose1

Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada

1 Corresponding author: Department of Medical Genetics, Faculty of Medicine, University of British Columbia, NCE, Room 419, 2125 East Mall, Vancouver, BC V6T 1Z4, Canada.
E-mail: ann.rose{at}ubc.ca

Here, we report genetic interactions with mdf-1(gk2)/MAD1 in Caenorhabditis elegans. Nine are evolutionarily conserved or phenotypic "interologs" and two are novel enhancers, hcp-1 and bub-3. We show that HCP-1 and HCP-2, the two CENP-F-related proteins, recently implicated in the spindle assembly checkpoint (SAC) function, do not have identical functions, since hcp-1(RNAi), but not hcp-2(RNAi), enhances the lethality of the SAC mutants.




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