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Originally published as Genetics Published Articles Ahead of Print on October 18, 2007.
Genetics, Vol. 177, 1915-1928, November 2007, Copyright © 2007
doi:10.1534/genetics.107.076497
Linkage Mapping of Domestication Loci in a Large Maize–Teosinte Backcross Resource
William H. Briggs*,1,
Michael D. McMullen
,
Brandon S. Gaut
and
John Doebley*
* Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USDA-ARS, University of Missouri, Columbia, Missouri 65211 and Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697
1 Corresponding author: Syngenta Seeds, 307 330th St., Stanton, MN 55018.
E-mail: william.briggs{at}syngenta.com
An ultimate objective of QTL mapping is cloning genes responsible for quantitative traits. However, projects seldom go beyond segments <5 cM without subsequent breeding and genotyping lines to identify additional crossovers in a genomic region of interest. We report on a QTL analysis performed as a preliminary step in the development of a resource for map-based cloning of domestication and improvement genes in corn. A large backcross (BC)1 population derived from a cross between maize (Zea mays ssp. mays) and teosinte (ssp. parviglumis) was grown for the analysis. A total of 1749 progenies were genotyped for 304 markers and measured for 22 morphological traits. The results are in agreement with earlier studies showing a small number of genomic regions having greater impact on the morphological traits distinguishing maize and teosinte. Despite considerable power to detect epistasis, few QTL interactions were identified. To create a permanent resource, seed of BC1 plants was archived and 1000 BC2S6 BC1-derived lines are in development for fine mapping and cloning. The identification of four BC1 progeny with crossovers in a single gene, tb1, indicated that enough derived lines already exist to clone many QTL without the need to generate and identify additional crossovers.
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