- THIS ARTICLE
- Full Text
- Full Text (PDF)
- Data Supplement
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Noor, M. A. F.
- Articles by Machado, C. A.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Noor, M. A. F.
- Articles by Machado, C. A.
Genetics, Vol. 177, 1417-1428, November 2007, Copyright © 2007
doi:10.1534/genetics.107.070672
Divergence Between the Drosophila pseudoobscura and D. persimilis Genome Sequences in Relation to Chromosomal Inversions
Mohamed A. F. Noor*,1,2,
David A. Garfield*,1,
Stephen W. Schaeffer
and
Carlos A. Machado
* Biology Department, Duke University, Durham, North Carolina 27708, Biology Department and Institute for Molecular Evolutionary Genetics, Pennsylvania State University, University Park, Pennsylvania 16802 and Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721
2 Corresponding author: Biology Department, Box 90338, Duke University, Durham, NC 27708.
E-mail: noor{at}duke.edu
As whole-genome sequence assemblies accumulate, a challenge is to determine how these can be used to address fundamental evolutionary questions, such as inferring the process of speciation. Here, we use the sequence assemblies of Drosophila pseudoobscura and D. persimilis to test hypotheses regarding divergence with gene flow. We observe low differentiation between the two genome sequences in pericentromeric and peritelomeric regions. We interpret this result as primarily a remnant of the correlation between levels of variation and local recombination rate observed within populations. However, we also observe lower differentiation far from the fixed chromosomal inversions distinguishing these species and greater differentiation within and near these inversions. This finding is consistent with models suggesting that chromosomal inversions facilitate species divergence despite interspecies gene flow. We also document heterogeneity among the inverted regions in their degree of differentiation, suggesting temporal differences in the origin of each inverted region consistent with the inversions arising during a process of divergence with gene flow. While this study provides insights into the speciation process using two single-genome sequences, it was informed by lower throughput but more rigorous examinations of polymorphism and divergence. This reliance highlights the need for complementary genomic and population genetic approaches for tackling fundamental evolutionary questions such as speciation.
This article has been cited by other articles:
 |
|
 |
|
  J. L. Strasburg, C. Scotti-Saintagne, I. Scotti, Z. Lai, and L. H. Rieseberg Genomic Patterns of Adaptive Divergence between Chromosomally Differentiated Sunflower Species Mol. Biol. Evol., June 1, 2009; 26(6): 1341 - 1355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Carneiro, N. Ferrand, and M. W. Nachman Recombination and Speciation: Loci Near Centromeres Are More Differentiated Than Loci Near Telomeres Between Subspecies of the European Rabbit (Oryctolagus cuniculus) Genetics, February 1, 2009; 181(2): 593 - 606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Kulathinal, S. M. Bennett, C. L. Fitzpatrick, and M. A. F. Noor Fine-scale mapping of recombination rate in Drosophila refines its correlation to diversity and divergence PNAS, July 22, 2008; 105(29): 10051 - 10056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bhutkar, S. W. Schaeffer, S. M. Russo, M. Xu, T. F. Smith, and W. M. Gelbart Chromosomal Rearrangement Inferred From Comparisons of 12 Drosophila Genomes Genetics, July 1, 2008; 179(3): 1657 - 1680. [Abstract] [Full Text] [PDF]
|
|