- THIS ARTICLE
- Full Text
- Full Text (PDF)
- Data Supplement
-
All Versions of this Article:
genetics.107.078964v1
177/2/847 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Deng, H.
- Articles by Zhang, H.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Deng, H.
- Articles by Zhang, H.
Originally published as Genetics Published Articles Ahead of Print on August 24, 2007.
Genetics, Vol. 177, 847-860, October 2007, Copyright © 2007
doi:10.1534/genetics.107.078964
The Flightless I Homolog, fli-1, Regulates Anterior/Posterior Polarity, Asymmetric Cell Division and Ovulation During Caenorhabditis elegans Development
Hansong Deng*,
,
Dan Xia*,,
Bin Fang and
Hong Zhang,1
* Graduate Program, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, People's Republic of China and National Institute of Biological Sciences, Beijing 102206, People's Republic of China
1 Corresponding author: National Institute of Biological Sciences, 7 Science Park Rd., Zhongguancun Life Science Park, Beijing 102206, People's Republic of China.
E-mail: zhanghong{at}nibs.ac.cn
Flightless I (Fli I) is an evolutionarily conserved member of the gelsolin family, containing actin-binding and severing activity in vitro. The physiological function of Fli I during animal development remains largely undefined. In this study, we reveal a key role of the Caenorhabditis elegans Fli I homolog, fli-1, in specifying asymmetric cell division and in establishing anterior–posterior polarity in the zygote. The fli-1 gene also regulates the cytokinesis of somatic cells and the development of germline and interacts with the phosphoinositol-signaling pathway in the regulation of ovulation. The fli-1 reporter gene shows that the localization of FLI-1 coincides with actin-rich regions and that the actin cytoskeleton is impaired in many tissues in the fli-1 mutants. Furthermore, the function of fli-1 in C. elegans can be functionally substituted by the Drosophila Fli I. Our studies demonstrate that fli-1 plays an important role in regulating the actin-dependent events during C. elegans development.
This article has been cited by other articles:
 |
|
 |
|
  T. Klaavuniemi, S. Yamashiro, and S. Ono Caenorhabditis elegans Gelsolin-like Protein 1 Is a Novel Actin Filament-severing Protein with Four Gelsolin-like Repeats J. Biol. Chem., September 19, 2008; 283(38): 26071 - 26080. [Abstract] [Full Text] [PDF]
|
|
|