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Genetics, Vol. 177, 723-735, October 2007, Copyright © 2007
doi:10.1534/genetics.107.075861
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Department of Biology, Indiana University, Bloomington, Indiana 47405
1 Corresponding author: Department of Biology, Indiana University, 1001 East Third St., Bloomington, IN 47405.
E-mail: plfoster{at}indiana.edu
or HUß, decrease adaptive mutation to Lac+ by both Pol IV-dependent and Pol IV-independent pathways. Additionally, HU mutations inhibit growth-dependent mutations without a reduction in the level of Pol IV. These effects of HU mutations on adaptive mutation and on growth-dependent mutations reveal novel functions for HU in mutagenesis.
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