Originally published as Genetics Published Articles Ahead of Print on August 24, 2007.

Genetics, Vol. 177, 1221-1226, October 2007, Copyright © 2007
doi:10.1534/genetics.107.070847

Modulation of Caenorhabditis elegans Transcription Factor Activity by HIM-8 and the Related Zinc-Finger ZIM Proteins

Hongliu Sun^*, Brian L. Nelms^,1, Sama F. Sleiman^,, Helen M. Chamberlin and Wendy Hanna-Rose^,2

^* Intercollege Graduate Degree Program in Genetics, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802 and Department of Molecular Genetics and Graduate Program in Molecular, Cellular, and Developmental Biology, Ohio State University, Columbus, Ohio 43210

² Corresponding author: 201 Life Science Bldg., Room 104D, Pennsylvania State University, University Park, PA.
E-mail: wxh21{at}psu.edu

The previously reported negative regulatory activity of HIM-8 on the Sox protein EGL-13 is shared by the HIM-8-related ZIM proteins. Furthermore, mutation of HIM-8 can modulate the effects of substitution mutations in the DNA-binding domains of at least four other transcription factors, suggesting broad regulatory activity by HIM-8.

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