Originally published as Genetics Published Articles Ahead of Print on July 29, 2007.

Genetics, Vol. 177, 661-666, September 2007, Copyright © 2007
doi:10.1534/genetics.107.076703

Caenorhabditis elegans SDF-9 Enhances Insulin/Insulin-Like Signaling Through Interaction With DAF-2

Victor L. Jensen^*, Patrice S. Albert and Donald L. Riddle^*,,1

^* Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada, Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211 and Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

¹ Corresponding author: Michael Smith Laboratories, 2185 East Mall, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
E-mail: driddle{at}interchange.ubc.ca

SDF-9 is a modulator of Caenorhabditis elegans insulin/IGF-1 signaling that may interact directly with the DAF-2 receptor. SDF-9 is a tyrosine phosphatase-like protein that, when mutated, enhances many partial loss-of-function mutants in the dauer pathway except for the temperature-sensitive mutant daf-2(m41). We propose that SDF-9 stabilizes the active phosphorylated state of DAF-2 or acts as an adaptor protein to enhance insulin-like signaling.

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