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Originally published as Genetics Published Articles Ahead of Print on July 29, 2007.

Genetics, Vol. 177, 661-666, September 2007, Copyright © 2007
doi:10.1534/genetics.107.076703

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Caenorhabditis elegans SDF-9 Enhances Insulin/Insulin-Like Signaling Through Interaction With DAF-2

Victor L. Jensen*, Patrice S. Albert{dagger} and Donald L. Riddle*,{ddagger},1

* Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada, {dagger} Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211 and {ddagger} Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

1 Corresponding author: Michael Smith Laboratories, 2185 East Mall, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
E-mail: driddle{at}interchange.ubc.ca

SDF-9 is a modulator of Caenorhabditis elegans insulin/IGF-1 signaling that may interact directly with the DAF-2 receptor. SDF-9 is a tyrosine phosphatase-like protein that, when mutated, enhances many partial loss-of-function mutants in the dauer pathway except for the temperature-sensitive mutant daf-2(m41). We propose that SDF-9 stabilizes the active phosphorylated state of DAF-2 or acts as an adaptor protein to enhance insulin-like signaling.






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Copyright © 2007 by the Genetics Society of America.