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Genetics, Vol. 177, 655-660, September 2007, Copyright © 2007
doi:10.1534/genetics.107.075762
Autophagy Genes unc-51 and bec-1 Are Required for Normal Cell Size in Caenorhabditis elegans
István Aladzsity*,
Márton L. Tóth*,
Tímea Sigmond*,
Emese Szabó*,
Bertalan Bicsák*,
János Barna*,
Ágnes Reg
s*,
László Orosz*,
Attila L. Kovács
and
Tibor Vellai*,1
* Department of Genetics, Eötvös Loránd University, Budapest, Hungary and Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, H-1117 Hungary
1 Corresponding author: Department of Genetics, Eötvös Loránd University, Pázmány Péter stny. 1/C, Budapest, H-1117, Hungary.
E-mail: vellai{at}falco.elte.hu
Here we show that in the nematode Caenorhabditis elegans mutational inactivation of two autophagy genes unc-51/atg1 and bec-1/atg6/beclin1 results in small body size without affecting cell number. Furthermore, loss-of-function mutations in unc-51 and bec-1 suppress the giant phenotype of mutant animals with aberrant insulin-like growth factor-1 (insulin/IGF-1) or transforming growth factor-ß (TGF-ß) signaling. This function for unc-51 and bec-1 in cell size control and their interaction with these two growth modulatory pathways may represent a link between the hormonal and nutritional regulation of cell growth.
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