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Genetics, Vol. 177, 113-121, September 2007, Copyright © 2007
doi:10.1534/genetics.107.075887
New Properties of Drosophila Fab-7 Insulator
Sergey Rodin1,2, Olga Kyrchanova1, Ekaterina Pomerantseva, Alexander Parshikov and Pavel Georgiev3
Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, Moscow 119334, Russia
3 Corresponding author: Institute of Gene Biology, Russian Academy of Sciences 34/5 Vavilov St., Moscow 119334, Russia.
E-mail: georgiev_p{at}mail.ru
In the Abd-B 3' cis-regulatory region, which is subdivided into a series of iab domains, boundary elements have previously been detected, including the Fab-7 element providing for the autonomous functioning of the iab-6 and iab-7 cis-regulatory domains. Here, it has been shown that a single copy of the 860-bp Fab-7 insulator effectively blocks the yellow and white enhancers. The eye and testis enhancers can stimulate the white promoter across the pair of Fab-7, which is indicative of a functional interaction between the insulators. Unexpectedly, Fab-7 has proved to lose the enhancer-blocking activity when placed near the white promoter. It seems likely that Fab-7 strengthens the relatively weak white promoter, which leads to the efficient enhancer–promoter interaction and insulator bypass.
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