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Genetics, Vol. 177, 113-121, September 2007, Copyright © 2007
doi:10.1534/genetics.107.075887

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New Properties of Drosophila Fab-7 Insulator

Sergey Rodin1,2, Olga Kyrchanova1, Ekaterina Pomerantseva, Alexander Parshikov and Pavel Georgiev3

Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, Moscow 119334, Russia

3 Corresponding author: Institute of Gene Biology, Russian Academy of Sciences 34/5 Vavilov St., Moscow 119334, Russia.
E-mail: georgiev_p{at}mail.ru

In the Abd-B 3' cis-regulatory region, which is subdivided into a series of iab domains, boundary elements have previously been detected, including the Fab-7 element providing for the autonomous functioning of the iab-6 and iab-7 cis-regulatory domains. Here, it has been shown that a single copy of the 860-bp Fab-7 insulator effectively blocks the yellow and white enhancers. The eye and testis enhancers can stimulate the white promoter across the pair of Fab-7, which is indicative of a functional interaction between the insulators. Unexpectedly, Fab-7 has proved to lose the enhancer-blocking activity when placed near the white promoter. It seems likely that Fab-7 strengthens the relatively weak white promoter, which leads to the efficient enhancer–promoter interaction and insulator bypass.




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O. Kyrchanova, S. Toshchakov, Y. Podstreshnaya, A. Parshikov, and P. Georgiev
Functional Interaction between the Fab-7 and Fab-8 Boundaries and the Upstream Promoter Region in the Drosophila Abd-B Gene
Mol. Cell. Biol., June 15, 2008; 28(12): 4188 - 4195.
[Abstract] [Full Text] [PDF]


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