Originally published as Genetics Published Articles Ahead of Print on May 4, 2007.

Genetics, Vol. 176, 2529-2540, August 2007, Copyright © 2007
doi:10.1534/genetics.106.064980

Bayesian Multiple Quantitative Trait Loci Mapping for Complex Traits Using Markers of the Entire Genome

Hanwen Huang^*, Chevonne D. Eversley, David W. Threadgill^, and Fei Zou^*,,1

^* Department of Biostatistics, Department of Genetics and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599

¹ Corresponding author: Department of Biostatistics, University of North Carolina, 3107D McGavran-Greenberg Hall, CB 7420, Chapel Hill, NC 27599.
E-mail: fzou{at}bios.unc.edu

A Bayesian methodology has been developed for multiple quantitative trait loci (QTL) mapping of complex binary traits that follow liability threshold models. Unlike most QTL mapping methods where only one or a few markers are used at a time, the proposed method utilizes all markers across the genome simultaneously. The outperformance of our Bayesian method over the traditional single-marker analysis and interval mapping has been illustrated via simulations and real data analysis to identify candidate loci associated with colorectal cancer.

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