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Originally published as Genetics Published Articles Ahead of Print on June 11, 2007.
Genetics, Vol. 176, 2015-2025, August 2007, Copyright © 2007
doi:10.1534/genetics.107.072413
SYP-3 Restricts Synaptonemal Complex Assembly to Bridge Paired Chromosome Axes During Meiosis in Caenorhabditis elegans
Sarit Smolikov*,
Andreas Eizinger*,
Kristina Schild-Prufert*,
Allison Hurlburt*,
Kent McDonald
,
JoAnne Engebrecht
,1,
Anne M. Villeneuve and
Mónica P. Colaiácovo*,2
* Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, Electron Microscope Laboratory, University of California, Berkeley, California 94720 and Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, California 94305
2 Corresponding author: Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, NRB-334, Boston, MA 02115.
E-mail: mcolaiacovo{at}genetics.med.harvard.edu
Synaptonemal complex (SC) formation must be regulated to occur only between aligned pairs of homologous chromosomes, ultimately ensuring proper chromosome segregation in meiosis. Here we identify SYP-3, a coiled-coil protein that is required for assembly of the central region of the SC and for restricting its loading to occur only in an appropriate context, forming structures that bridge the axes of paired meiotic chromosomes in Caenorhabditis elegans. We find that inappropriate loading of central region proteins interferes with homolog pairing, likely by triggering a premature change in chromosome configuration during early prophase that terminates the search for homologs. As a result, syp-3 mutants lack chiasmata and exhibit increased chromosome missegregation. Altogether, our studies lead us to propose that SYP-3 regulates synapsis along chromosomes, contributing to meiotic progression in early prophase.
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Genetics 2007 176: NP.
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  S. Smolikov, A. Eizinger, A. Hurlburt, E. Rogers, A. M. Villeneuve, and M. P. Colaiacovo Synapsis-Defective Mutants Reveal a Correlation Between Chromosome Conformation and the Mode of Double-Strand Break Repair During Caenorhabditis elegans Meiosis Genetics, August 1, 2007; 176(4): 2027 - 2033. [Abstract] [Full Text] [PDF]
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