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Originally published as Genetics Published Articles Ahead of Print on July 1, 2007.

Genetics, Vol. 176, 1945-1955, August 2007, Copyright © 2007
doi:10.1534/genetics.106.066746

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Cytotype Regulation by Telomeric P Elements in Drosophila melanogaster: Evidence for Involvement of an RNA Interference Gene

Michael J. Simmons1, Don-Felix Ryzek, Cecile Lamour, Joseph W. Goodman, Nicole E. Kummer and Peter J. Merriman

Department of Genetics, Cell Biology, and Development, University of Minnesota, St. Paul, Minnesota 55108-1095

1 Corresponding author: Department of Genetics, Cell Biology, and Development, 250 BioScience Center, University of Minnesota, 1445 Gortner Ave., St. Paul, MN 55108-1095.
E-mail: simmo004{at}umn.edu

P elements inserted at the left telomere of the X chromosome evoke the P cytotype, a maternally inherited condition that regulates the P-element family in the Drosophila germline. This regulation is completely disrupted in stocks heterozygous for mutations in aubergine, a gene whose protein product is involved in RNA interference. However, cytotype is not disrupted in stocks heterozygous for mutations in two other RNAi genes, piwi and homeless (spindle-E), or in a stock heterozygous for a mutation in the chromatin protein gene Enhancer of zeste. aubergine mutations exert their effects in the female germline, where the P cytotype is normally established and through which it is maintained. These effects are transmitted maternally to offspring of both sexes independently of the mutations themselves. Lines derived from mutant aubergine stocks reestablish the P cytotype quickly, unlike lines derived from stocks heterozygous for a mutation in Suppressor of variegation 205, the gene that encodes the telomere-capping protein HP1. Cytotype regulation by telomeric P elements may be tied to a system that uses RNAi to regulate the activities of telomeric retrotransposons in Drosophila.


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M. J. Simmons, J. B. Niemi, D.-F. Ryzek, C. Lamour, J. W. Goodman, W. Kraszkiewicz, and R. Wolff
Cytotype Regulation by Telomeric P Elements in Drosophila melanogaster: Interactions With P Elements From M' Strains
Genetics, August 1, 2007; 176(4): 1957 - 1966.
[Abstract] [Full Text] [PDF]


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