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Originally published as Genetics Published Articles Ahead of Print on May 16, 2007.
Genetics, Vol. 176, 1591-1607, July 2007, Copyright © 2007
doi:10.1534/genetics.106.067116
The Plexin PLX-2 and the Ephrin EFN-4 Have Distinct Roles in MAB-20/Semaphorin 2A Signaling in Caenorhabditis elegans Morphogenesis
Fumi Nakao*,1,
Martin L. Hudson
,1,
Motoshi Suzuki*,
Zachary Peckler,
Rie Kurokawa*,
Zhicen Liu*,
Keiko Gengyo-Ando
,
Akira Nukazuka*,
Takashi Fujii*,
Fumikazu Suto*,
Yukimasa Shibata*,
Go Shioi*,
Hajime Fujisawa*,
Shohei Mitani,
Andrew D. Chisholm and
Shin Takagi*,2
* Division of Biological Science, Nagoya University Graduate School of Science, Chikusa-ku, Nagoya 464-8602, Japan, Department of Molecular, Cell and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz, California 95064 and Department of Physiology, Tokyo Women's Medical University School of Medicine, Tokyo 162-8666, Japan
2 Corresponding author: Division of Biological Science, Nagoya University Graduate School of Science, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan.
E-mail: i45116a{at}nucc.cc.nagoya-u.ac.jp
Semaphorins are extracellular proteins that regulate axon guidance and morphogenesis by interacting with a variety of cell surface receptors. Most semaphorins interact with plexin-containing receptor complexes, although some interact with non-plexin receptors. Class 2 semaphorins are secreted molecules that control axon guidance and epidermal morphogenesis in Drosophila and Caenorhabditis elegans. We show that the C. elegans class 2 semaphorin MAB-20 binds the plexin PLX-2. plx-2 mutations enhance the phenotypes of hypomorphic mab-20 alleles but not those of mab-20 null alleles, indicating that plx-2 and mab-20 act in a common pathway. Both mab-20 and plx-2 mutations affect epidermal morphogenesis during embryonic and in postembryonic development. In both contexts, plx-2 null mutant phenotypes are much less severe than mab-20 null phenotypes, indicating that PLX-2 is not essential for MAB-20 signaling. Mutations in the ephrin efn-4 do not synergize with mab-20, indicating that EFN-4 may act in MAB-20 signaling. EFN-4 and PLX-2 are coexpressed in the late embryonic epidermis where they play redundant roles in MAB-20-dependent cell sorting.
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