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Originally published as Genetics Published Articles Ahead of Print on May 4, 2007.

Genetics, Vol. 176, 1501-1510, July 2007, Copyright © 2007
doi:10.1534/genetics.107.072769

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A Complex Genetic Interaction Between Arabidopsis thaliana TOC1 and CCA1/LHY in Driving the Circadian Clock and in Output Regulation

Zhaojun Ding*, Mark R. Doyle{dagger}, Richard M. Amasino{dagger} and Seth J. Davis*,1

* Max Planck Institute for Plant Breeding Research, D-50829 Cologne, Germany and {dagger} Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706-1544

1 Corresponding author: Department of Plant Developmental Biology, Max Planck Institute for Plant Breeding Research, Carl-von-Linne-Weg 10, Cologne 50829, Germany.
E-mail: davis{at}mpiz-koeln.mpg.de

It has been proposed that CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) together with TIMING OF CAB EXPRESSION 1 (TOC1) make up the central oscillator of the Arabidopsis thaliana circadian clock. These genes thus drive rhythmic outputs, including seasonal control of flowering and photomorphogenesis. To test various clock models and to disclose the genetic relationship between TOC1 and CCA1/LHY in floral induction and photomorphogenesis, we constructed the cca1 lhy toc1 triple mutant and cca1 toc1 and lhy toc1 double mutants and tested various rhythmic responses and circadian output regulation. Here we report that rhythmic activity was dramatically attenuated in cca1 lhy toc1. Interestingly, we also found that TOC1 regulates the floral transition in a CCA1/LHY-dependent manner while CCA1/LHY functions upstream of TOC1 in regulating a photomorphogenic process. This suggests to us that TOC1 and CCA1/LHY participate in these two processes through different strategies. Collectively, we have used genetics to provide direct experimental support of previous modeling efforts where CCA1/LHY, along with TOC1, drives the circadian oscillator and have shown that this clock is essential for correct output regulation.


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Genetics 2007 176: NP. [Full Text]  



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S. Ito, Y. Niwa, N. Nakamichi, H. Kawamura, T. Yamashino, and T. Mizuno
Insight into Missing Genetic Links Between Two Evening-Expressed Pseudo-Response Regulator Genes TOC1 and PRR5 in the Circadian Clock-Controlled Circuitry in Arabidopsis thaliana
Plant Cell Physiol., February 1, 2008; 49(2): 201 - 213.
[Abstract] [Full Text] [PDF]


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