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Genetics, Vol. 176, 1417-1429, July 2007, Copyright © 2007
doi:10.1534/genetics.107.072876
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,1
,
,1,2
* Banting and Best Department of Medical Research, Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada,
Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada and
Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada
2 Corresponding author: CCBR, University of Toronto, 160 College St., Room 1206, Toronto, ON M5S 3E1, Canada.
E-mail: grant.brown{at}utoronto.ca
, tof1
, and csm3
and identified additive cohesion defects that indicated the existence of at least two pathways that contribute to sister-chromatid cohesion. To understand the relationship of other nonessential cohesion genes with respect to these two pathways, pairwise combinations of deletion and temperature-sensitive alleles were tested for cohesion defects. These data defined two cohesion pathways, one containing CSM3, TOF1, CTF4, and CHL1, and the second containing MRC1, CTF18, CTF8, and DCC1. Furthermore, we found that the nonessential genes are not important for the maintenance of cohesion at G2/M. Thus, our data suggest that nonessential cohesion genes make critical redundant contributions to the establishment of sister-chromatid cohesion and define two cohesion pathways, thereby establishing a framework for understanding the role of nonessential genes in sister-chromatid cohesion. This article has been cited by other articles:
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A. B. Ansbach, C. Noguchi, I. W. Klansek, M. Heidlebaugh, T. M. Nakamura, and E. Noguchi RFCCtf18 and the Swi1-Swi3 Complex Function in Separate and Redundant Pathways Required for the Stabilization of Replication Forks to Facilitate Sister Chromatid Cohesion in Schizosaccharomyces pombe Mol. Biol. Cell, February 1, 2008; 19(2): 595 - 607. [Abstract] [Full Text] [PDF] |
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B. Hodgson, A. Calzada, and K. Labib Mrc1 and Tof1 Regulate DNA Replication Forks in Different Ways during Normal S Phase Mol. Biol. Cell, October 1, 2007; 18(10): 3894 - 3902. [Abstract] [Full Text] [PDF] |
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