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Originally published as Genetics Published Articles Ahead of Print on April 15, 2007.
Genetics, Vol. 176, 1355-1358, June 2007, Copyright © 2007
doi:10.1534/genetics.107.073676
Loss-of-Function Alleles of the JIL-1 Histone H3S10 Kinase Enhance Position-Effect Variegation at Pericentric Sites in Drosophila Heterochromatin
Xiaomin Bao, Huai Deng, Jørgen Johansen, Jack Girton and Kristen M. Johansen1
Department of Biochemistry, Biophysics, and Molecular Biology Iowa State University Ames, Iowa 50011
1 Corresponding author: Department of Biochemistry, Biophysics, and Molecular Biology, 3154 Molecular Biology Bldg., Iowa State University, Ames, IA 50011.
E-mail: kristen{at}iastate.edu
In this study we show that loss-of-function alleles of the JIL-1 histone H3S10 kinase act as enhancers of position-effect variegation at pericentric sites whereas the gain-of-function JIL-1Su(var)3-1[3] allele acts as a suppressor strongly supporting a functional role for JIL-1 in maintaining euchromatic chromatin and counteracting heterochromatic spreading and gene silencing.
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Genetics 2007 176: NP.
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