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Originally published as Genetics Published Articles Ahead of Print on April 3, 2007.
Genetics, Vol. 176, 721-724, May 2007, Copyright © 2007
doi:10.1534/genetics.106.067264
Survival Quantitative Trait Locus Fine Mapping by Measuring and Testing for Hardy–Weinberg and Linkage Disequilibrium
J. Casellas1
Grup de Recerca en Remugants, Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
1 Address for correspondence: Genètica i Millora Animal, IRTA-Lleida, 25198 Lleida, Spain.
E-mail: joaquim.casellas{at}irta.es
I show that fine-scale localization of a survival-related locus can be accomplished on the basis of deviations from Hardy–Weinberg equilibrium and linkage disequilibrium at closely linked marker loci. The method is based on 
2-tests and they can be performed for age-specific samples of alive (or dead) individuals, as for combined samples of alive and dead individuals.