Originally published as Genetics Published Articles Ahead of Print on March 4, 2007.

Genetics, Vol. 176, 703-709, May 2007, Copyright © 2007
doi:10.1534/genetics.106.070201

The Caenorhabditis elegans Rad17 Homolog HPR-17 Is Required for Telomere Replication

Julie Boerckel^*, Dana Walker and Shawn Ahmed^*,,1

^* Department of Biology and Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599-3280

¹ Corresponding author: Department of Genetics, Coker Hall, University of North Carolina, Chapel Hill, NC 27599-3280.
E-mail: shawn{at}med.unc.edu

Subunits of the Rad9/Rad1/Hus1 (9-1-1) proliferating cell nuclear antigen (PNCA)-like sliding clamp are required for DNA damage responses and telomerase-mediated telomere replication in the nematode Caenorhabditis elegans. PCNA sliding clamps are loaded onto DNA by a replication factor C (RFC) clamp loader. The C. elegans Rad17 RFC clamp loader homolog, hpr-17, functions in the same pathway as the 9-1-1 complex with regard to both the DNA damage response and telomerase-mediated telomere elongation. Thus, hpr-17 defines an RFC-like complex that facilitates telomerase activity in vivo in C. elegans.

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