Originally published as Genetics Published Articles Ahead of Print on January 21, 2007.

Genetics, Vol. 175, 2029-2037, April 2007, Copyright © 2007
doi:10.1534/genetics.107.070987

A Role for Caenorhabditis elegans Chromatin-Associated Protein HIM-17 in the Proliferation vs. Meiotic Entry Decision

Jessica B. Bessler*,1, Kirthi C. Reddy*,1, Michiko Hayashi*, Jonathan Hodgkin{dagger} and Anne M. Villeneuve*,2

* Department of Developmental Biology and Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 and {dagger} Genetics Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom

2 Corresponding author: Department of Developmental Biology, Stanford University School of Medicine, 279 Campus Dr., Beckman Center B300, Stanford, CA 94305-5329.
E-mail: villen{at}cmgm.stanford.edu

Chromatin-associated protein HIM-17 was previously shown to function in the chromosomal events of meiotic prophase. Here we report an additional role for HIM-17 in regulating the balance between germ cell proliferation and meiotic development. A cryptic function for HIM-17 in promoting meiotic entry and/or inhibiting proliferation was revealed by defects in germline organization in him-17 mutants grown at high temperature (25°) and by a synthetic tumorous germline phenotype in glp-1(ar202); him-17 mutants at 15°.


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Genetics 2007 175: NP. [Full Text]