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Originally published as Genetics Published Articles Ahead of Print on February 4, 2007.
Genetics, Vol. 175, 1987-1997, April 2007, Copyright © 2007
doi:10.1534/genetics.106.067108
How Repeatable Are Associations Between Polymorphisms in achaete–scute and Bristle Number Variation in Drosophila?
Jonathan D. Gruber*,1,
Anne Genissel
,
Stuart J. Macdonald
and
Anthony D. Long*
* Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697, Section of Evolution and Ecology, University of California, Davis, California 95616 and Department of Ecology and Evolutionary Biology, Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045
1 Corresponding author: Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697.
E-mail: gruberjd{at}uci.edu
Currently, the relevance of common genetic variants—particularly those significantly associated with phenotypic variation in laboratory studies—to standing phenotypic variation in the wild is poorly understood. To address this, we quantified the relationship between achaete–scute complex (ASC) polymorphisms and Drosophila bristle number phenotypes in several new population samples. MC22 is a biallelic, nonrepetitive-length polymorphism 97 bp downstream of the scute transcript. It has been previously shown to be associated with sternopleural bristle number variation in both sexes in a set of isogenic lines. We replicated this association in a large cohort of wild-caught Drosophila melanogaster. We also detected a significant association at MC22 in an outbred population maintained under laboratory conditions for 
25 years, but the phenotypic effects in this sample were opposite from the direction estimated in the initial study. Finally, no significant associations were detected in a second large wild-caught cohort or in a set of 134 nearly isogenic lines. Our ability to repeat the initial association in wild samples suggests that it was not spurious. Nevertheless, inconsistent results from the other three panels suggest that the relationship between polymorphic genetic markers and loci contributing to continuous variation is not a simple one.
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Genetics 2007 175: NP.
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