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Genetics, Vol. 175, 1649-1664, April 2007, Copyright © 2007
doi:10.1534/genetics.106.066274
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* Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 and
Center for Biological Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
1 Corresponding author: Department of Biological Sciences, 274 Crawford Hall, University of Pittsburgh, Pittsburgh, PA 15260.
E-mail: jbrodsky{at}pitt.edu
yeast exhibit phenotypes consistent with cell-wall defects and that these phenotypes were improved by Mid2p or Pkc1p overexpression or by overexpression of activated downstream components in the PKC pathway. Yeast containing a thermosensitive allele in the gene encoding Hsp90 also exhibited cell-wall defects, and Mid2p or Pkc1p overexpression improved the growth of these cells at elevated temperatures. To determine the physiological basis for suppression of the ydj1
growth defect, wild-type and ydj1
yeast were examined by electron microscopy and we found that Mid2p overexpression thickened the mutant's cell wall. Together, these data provide the first direct link between cytoplasmic chaperone function and cell-wall integrity and suggest that chaperones orchestrate the complex biogenesis of this structure. This article has been cited by other articles:
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C. N. Martineau, J.-M. Beckerich, and M. Kabani Flo11p-Independent Control of "Mat" Formation by Hsp70 Molecular Chaperones and Nucleotide Exchange Factors in Yeast Genetics, November 1, 2007; 177(3): 1679 - 1689. [Abstract] [Full Text] [PDF] |
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