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Originally published as Genetics Published Articles Ahead of Print on December 6, 2006.
Genetics, Vol. 175, 1533-1537, March 2007, Copyright © 2007
doi:10.1534/genetics.106.068130
Telomere Dysfunction Drives Increased Mutation by Error-Prone Polymerases Rev1 and 
in Saccharomyces cerevisiae
Damon H. Meyer*,
and
Adam M. Bailis*,1
* Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010-0269 and City of Hope Graduate School of Biological Sciences, Duarte, California 91010-3000
1 Corresponding author: Division of Molecular Biology, Beckman Institute of the City of Hope, 1450 E. Duarte Rd., Duarte, CA 91010-3000.
E-mail: abailis{at}bricoh.edu.
Using a model system, we have shown that replicative senescence is accompanied by a 16-fold increase in base substitution and frameshift mutations near a chromosome end. The increase was dependent on error-prone polymerases required for the mutagenic response to DNA lesions that block the replication fork.
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