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Originally published as Genetics Published Articles Ahead of Print on December 18, 2006.

Genetics, Vol. 175, 1163-1174, March 2007, Copyright © 2007
doi:10.1534/genetics.106.067959

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Identification of Genes That Interact With Drosophila liquid facets

Suk Ho Eun1, Kristi Lea1,2, Erin Overstreet3, Samuel Stevens, Ji-Hoon Lee and Janice A. Fischer1,4

Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712

4 Corresponding author: Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Moffett Molecular Biology Bldg., 2500 Speedway, Austin, TX 78712.
E-mail: jaf{at}mail.utexas.edu

We have performed mutagenesis screens of the Drosophila X chromosome and the autosomes for dominant enhancers of the rough eye resulting from overexpression of liquid facets. The liquid facets gene encodes the homolog of vertebrate endocytic Epsin, an endocytic adapter protein. In Drosophila, Liquid facets is a core component of the Notch signaling pathway required in the signaling cells for ligand endocytosis and signaling. Why ligand internalization by the signaling cells is essential for signaling is a mystery. The requirement for Liquid facets is a hint at the answer, and the genes identified in this screen provide further clues. Mutant alleles of clathrin heavy chain, Rala, split ends, and auxilin were identified as enhancers. We describe the mutant alleles and mutant phenotypes of Rala and aux. We discuss the relevance of all of these genetic interactions to the function of Liquid facets in Notch signaling.






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Copyright © 2007 by the Genetics Society of America.