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Originally published as Genetics Published Articles Ahead of Print on December 6, 2006.
Genetics, Vol. 175, 963-967, February 2007, Copyright © 2007
doi:10.1534/genetics.106.067850
Xlf1 Is Required for DNA Repair by Nonhomologous End Joining in Schizosaccharomyces pombe
Santiago Cavero, Charly Chahwan and Paul Russell1
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 90237
1 Corresponding author: Department of Molecular Biology, The Scripps Research Institute, MB-3, 10550 North Torrey Pines Rd., La Jolla, CA 90237.
E-mail: prussell{at}scripps.edu
The accurate repair of DNA double-strand breaks is essential for cell survival and maintenance of genome integrity. Here we describe xlf1+, a gene in the fission yeast Schizosaccharomyces pombe that is required for repair of double-strand breaks by nonhomologous end joining during G1 phase of the cell cycle. Xlf1 is the ortholog of budding yeast Nej1 and human XLF/Cernunnos proteins.