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Originally published as Genetics Published Articles Ahead of Print on December 6, 2006.

Genetics, Vol. 175, 505-511, February 2007, Copyright © 2007
doi:10.1534/genetics.106.067595

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An Analysis of Univalent Segregation in Meiotic Mutants of Arabidopsis thaliana: A Possible Role for Synaptonemal Complex

Mónica Pradillo*,1, Eva López*,1, Concepción Romero*, Eugenio Sánchez-Morán{dagger}, Nieves Cuñado* and Juan L. Santos*,2

* Departamento de Genética, Facultad de Biología, Universidad Complutense de Madrid, Madrid 28040, Spain and {dagger} School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom

2 Corresponding author: Departamento de Genética, Facultad de Biología, Universidad Complutense de Madrid, C/José Antonio Nováis 2, Madrid 28040, Spain. 
E-mail: jlsc53{at}bio.ucm.es

During first meiotic prophase, homologous chromosomes are normally kept together by both crossovers and synaptonemal complexes (SC). In most eukaryotes, the SC disassembles at diplotene, leaving chromosomes joined by chiasmata. The correct co-orientation of bivalents at metaphase I and the reductional segregation at anaphase I are facilitated by chiasmata and sister-chromatid cohesion. In the absence of meiotic reciprocal recombination, homologs are expected to segregate randomly at anaphase I. Here, we have analyzed the segregation of homologous chromosomes at anaphase I in four meiotic mutants of Arabidopsis thaliana, spo11-1-3, dsy1, mpa1, and asy1, which show a high frequency of univalents at diplotene. The segregation pattern of chromosomes 2, 4, and 5 was different in each mutant. Homologous univalents segregated randomly in spo11-1-3, whereas they did not in dsy1 and mpa1. An intermediate situation was observed in asy1. Also, we have found a parallelism between this behavior and the synaptic pattern displayed by each mutant. Thus, whereas spo11-1-3 and asy1 showed low amounts of SC stretches, dsy1 and mpa1 showed full synapsis. These findings suggest that in Arabidopsis there is a system, depending on the SC formation, that would facilitate regular disjunction of homologous univalents to opposite poles at anaphase I.


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Genetics 2007 175: NP. [Full Text]  



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