Originally published as Genetics Published Articles Ahead of Print on November 16, 2006.

Genetics, Vol. 175, 375-398, January 2007, Copyright © 2007
doi:10.1534/genetics.106.061457

Linkage Maps of the dwarf and Normal Lake Whitefish (Coregonus clupeaformis) Species Complex and Their Hybrids Reveal the Genetic Architecture of Population Divergence

S. M. Rogers*,1, N. Isabel{dagger} and L. Bernatchez*

* Québec Océan, Département de Biologie, Université Laval, Sainte-Foy, Québec G1K 7P4, Canada and {dagger} Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Sainte-Foy, Québec G1V 4C7, Canada

1 Corresponding author: Department of Zoology, University of British Columbia, 2370-6270 University Blvd., Vancouver, BC V6T 1Z4, Canada.
E-mail: srogers{at}zoology.ubc.ca

Elucidating the genetic architecture of population divergence may reveal the evolution of reproductive barriers and the genomic regions implicated in the process. We assembled genetic linkage maps for the dwarf and Normal lake whitefish species complex and their hybrids. A total of 877 AFLP loci and 30 microsatellites were positioned. The homology of mapped loci between families supported the existence of 34 linkage groups (of 40n expected) exhibiting 83% colinearity among linked loci between these two families. Classes of AFLP markers were not randomly distributed among linkage groups. Both AFLP and microsatellites exhibited deviations from Mendelian expectations, with 30.4% exhibiting significant segregation distortion across 28 linkage groups of the four linkage maps in both families (P < 0.00001). Eight loci distributed over seven homologous linkage groups were significantly distorted in both families and the level of distortion, when comparing homologous loci of the same phase between families, was correlated (Spearman R = 0.378, P = 0.0021). These results suggest that substantial divergence incurred during allopatric glacial separation and subsequent sympatric ecological specialization has resulted in several genomic regions that are no longer complementary between dwarf and Normal populations issued from different evolutionary glacial lineages.




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