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Originally published as Genetics Published Articles Ahead of Print on October 22, 2006.
Genetics, Vol. 175, 185-197, January 2007, Copyright © 2007
doi:10.1534/genetics.106.062976
Disruption of Genetic Interaction Between Two Autosomal Regions and the X Chromosome Causes Reproductive Isolation Between Mouse Strains Derived From Different Subspecies
Ayako Oka*,
,
Toshihiro Aoto
,
Yoshikazu Totsuka,
Riichi Takahashi,
Masatsugu Ueda,
Akihiko Mita,
Noriko Sakurai-Yamatani,
Hiromi Yamamoto,
Satoshi Kuriki*,
,
Nobuo Takagi**,
Kazuo Moriwaki and
Toshihiko Shiroishi*,,1
* Transdisciplinary Research Integration Center, Research Organization of Information and Systems, Toranomon, Tokyo, Japan 105-0001, Mammalian Genetics Laboratory, National Institute of Genetics, Research Organization of Information and Systems, Mishima, Shizuoka, Japan 411-8540, The YS Institute, Utsunomiya, Tochigi, Japan 321-0973, Department of Mathematical Analysis and Statistical Inference, Institute of Statistical Mathematics, Research Organization of Information and Systems, Tokyo, Japan 106-8569, ** Department of Economics, Hokusei Gakuen University, Sapporo, Hokkaido, Japan 004-8631 and RIKEN BioResource Center, Tsukuba, Ibaraki, Japan 305-0074
1 Corresponding author: Mammalian Genetics Laboratory, National Institute of Genetics, Yata 1111, Mishima, Shizuoka-ken 411-8540, Japan.
E-mail: tshirois{at}lab.nig.ac.jp
Reproductive isolation that initiates speciation is likely caused by incompatibility among multiple loci in organisms belonging to genetically diverging populations. Laboratory C57BL/6J mice, which predominantly originated from Mus musculus domesticus, and a MSM/Ms strain derived from Japanese wild mice (M. m. molossinus, genetically close to M. m. musculus) are reproductively isolated. Their F1 hybrids are fertile, but successive intercrosses result in sterility. A consomic strain, C57BL/6J-ChrXMSM, which carries the X chromosome of MSM/Ms in the C57BL/6J background, shows male sterility, suggesting a genetic incompatibility of the MSM/Ms X chromosome and other C57BL/6J chromosome(s). In this study, we conducted genomewide linkage analysis and subsequent QTL analysis using the sperm shape anomaly that is the major cause of the sterility of the C57BL/6J-ChrXMSM males. These analyses successfully detected significant QTL on chromosomes 1 and 11 that interact with the X chromosome. The introduction of MSM/Ms chromosomes 1 and 11 into the C57BL/6J-ChrXMSM background failed to restore the sperm-head shape, but did partially restore fertility. This result suggests that this genetic interaction may play a crucial role in the reproductive isolation between the two strains. A detailed analysis of the male sterility by intracytoplasmic sperm injection and zona-free in vitro fertilization demonstrated that the C57BL/6J-ChrXMSM spermatozoa have a defect in penetration through the zona pellucida of eggs.
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Genetics 2007 175: NP.
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