- THIS ARTICLE
- Full Text
- Full Text (PDF)
- Data Supplement
-
All Versions of this Article:
genetics.106.065680v1
175/1/125 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Pepple, K. L.
- Articles by Mardon, G.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Pepple, K. L.
- Articles by Mardon, G.
Originally published as Genetics Published Articles Ahead of Print on November 16, 2006.
Genetics, Vol. 175, 125-141, January 2007, Copyright © 2007
doi:10.1534/genetics.106.065680
A Genetic Screen in Drosophila for Genes Interacting With senseless During Neuronal Development Identifies the Importin moleskin
Kathryn L. Pepple*,1,
Aimée E. Anderson*,1,
Benjamin J. Frankfort*,2 and
Graeme Mardon*,
,
,
,**,3
* Department of Molecular and Human Genetics, Department of Pathology, Department of Neuroscience, Department of Ophthalmology and ** Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030
3 Corresponding author: Department of Pathology, Room T222, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030.
E-mail: gmardon{at}bcm.tmc.edu
Senseless (Sens) is a conserved transcription factor required for normal development of the Drosophila peripheral nervous system. In the Drosophila retina, sens is necessary and sufficient for differentiation of R8 photoreceptors and interommatidial bristles (IOBs). When Sens is expressed in undifferentiated cells posterior to the morphogenetic furrow, ectopic IOBs are formed. This phenotype was used to identify new members of the sens pathway in a dominant modifier screen. Seven suppressor and three enhancer complementation groups were isolated. Three groups from the screen are the known genes Delta, lilliputian, and moleskin/DIM-7 (msk), while the remaining seven groups represent novel genes with previously undefined functions in neural development. The nuclear import gene msk was identified as a potent suppressor of the ectopic interommatidial bristle phenotype. In addition, msk mutant adult eyes are extremely disrupted with defects in multiple cell types. Reminiscent of the sens mutant phenotype, msk eyes demonstrate reductions in the number of R8 photoreceptors due to an R8 to R2,5 fate switch, providing genetic evidence that Msk is a component of the sens pathway. Interestingly, in msk tissue, the loss of R8 fate occurs earlier than with sens and suggests a previously unidentified stage of R8 development between atonal and sens.
This article has been cited by other articles:
 |
|
 |
|
  K. L. Pepple, M. Atkins, K. Venken, K. Wellnitz, M. Harding, B. Frankfort, and G. Mardon Two-step selection of a single R8 photoreceptor: a bistable loop between senseless and rough locks in R8 fate Development, December 15, 2008; 135(24): 4071 - 4079. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. James, T. A. Bunch, S. Krishnamoorthy, L. A. Perkins, and D. L. Brower Nuclear Localization of the ERK MAP Kinase Mediated by Drosophila {alpha}PS2betaPS Integrin and Importin-7 Mol. Biol. Cell, October 1, 2007; 18(10): 4190 - 4199. [Abstract] [Full Text] [PDF]
|
|
|