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Originally published as Genetics Published Articles Ahead of Print on October 8, 2006.

Genetics, Vol. 174, 2249-2254, December 2006, Copyright © 2006
doi:10.1534/genetics.106.063099

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The Histone Deubiquitinating Enzyme Ubp10 Is Involved in rDNA Locus Control in Saccharomyces cerevisiae by Affecting Sir2p Association

Luciano Calzari, Ivan Orlandi, Lilia Alberghina and Marina Vai1

Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, 20126 Milano, Italy

1 Corresponding author: Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, P.zza della Scienza 2, 20126 Milano, Italy.
E-mail: marina.vai{at}unimib.it

Histone modifications influence chromatin structure and thus regulate the accessibility of DNA to replication, recombination, repair, and transcription. We show here that the histone deubiquitinating enzyme Ubp10 contributes to the formation/maintenance of silenced chromatin at the rDNA by affecting Sir2p association.






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