help button home button Genetics J Exp Med
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Originally published as Genetics Published Articles Ahead of Print on October 22, 2006.

Genetics, Vol. 174, 2119-2127, December 2006, Copyright © 2006
doi:10.1534/genetics.106.063057

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow All Versions of this Article:
genetics.106.063057v1
174/4/2119    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Related articles in Genetics
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ojeda, A.
Right arrow Articles by Pérez-Enciso, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ojeda, A.
Right arrow Articles by Pérez-Enciso, M.

Unexpected High Polymorphism at the FABP4 Gene Unveils a Complex History for Pig Populations

Ana Ojeda*, Julio Rozas{dagger}, Josep M. Folch* and Miguel Pérez-Enciso*,{ddagger},1

* Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain, {dagger} Departament de Genètica, Universitat de Barcelona, 08071 Barcelona, Spain and {ddagger} Institut Català de Recerca i Estudis Avançats, 08010 Barcelona, Spain

1 Corresponding author: Departament de Ciència Animal i dels Aliments, Facultat de Veterinária, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
E-mail: miguel.perez{at}uab.es

Fatty acid bing protein 4 (FABP4) plays a key role in fat regulation in mammals and is a strong positional candidate gene for the FAT1 quantitative trait locus located on porcine chromosome 4. DNA resequencing of the FABP4 gene region in 23 pigs from 10 breeds and wild boar revealed 134 variants in 6.4 kb, representing a silent nucleotide diversity of {pi}S = 0.01, much higher than reported so far in animal domestic species. Moreover, this diversity was highly structured. Also strikingly, the FABP4 phylogenetic tree did not show any geographical or breed origin clustering, with distant breeds sharing similar haplotypes and some of the most heterozygous samples pertaining to highly inbred animals like Iberian Guadyerbas (inbreeding coefficient ~0.3) or British Tamworth. In contrast, the cytochrome b (mtDNA) phylogenetic tree was coherent with geographical origin. The estimated age of the most recent common ancestor for the most divergent Iberian or Tamworth haplotypes was much older than domestication. An additional panel of 100 pigs from 8 different breeds and wild boar from Spain, Tunisia, Sardinia, and Japan was genotyped for seven selected single nucleotide polymorphisms and shows that high variability at the porcine FABP4 is the rule rather than the exception. Pig populations, even highly inbred, can maintain high levels of variability for surprisingly long periods of time.


Related articles in Genetics:

ISSUE HIGHLIGHTS

Genetics 2006 174: 0. [Full Text]  



This article has been cited by other articles:


Home page
 GeneticsHome page
A. Ojeda, L.-S. Huang, J. Ren, A. Angiolillo, I.-C. Cho, H. Soto, C. Lemus-Flores, S. M. Makuza, J. M. Folch, and M. Perez-Enciso
Selection in the Making: A Worldwide Survey of Haplotypic Diversity Around a Causative Mutation in Porcine IGF2
Genetics, March 1, 2008; 178(3): 1639 - 1652.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the Genetics Society of America.