help button home button Genetics AJP: Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Originally published as Genetics Published Articles Ahead of Print on October 8, 2006.

Genetics, Vol. 174, 2033-2044, December 2006, Copyright © 2006
doi:10.1534/genetics.106.064113

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplement to Bartolome and Charlesworth 2006
Right arrow All Versions of this Article:
genetics.106.064113v1
174/4/2033    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bartolomé, C.
Right arrow Articles by Charlesworth, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bartolomé, C.
Right arrow Articles by Charlesworth, B.

Evolution of Amino-Acid Sequences and Codon Usage on the Drosophila miranda Neo-Sex Chromosomes

Carolina Bartolomé1 and Brian Charlesworth

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom

1 Corresponding author: Grupo de Medicina Xenómica (USC), Unidad de Medicina Molecular, Hospital Clínico Universitario de Santiago, Edificio Consultas (planta-2), 15706 Santiago de Compostela, Spain.
E-mail: cbhusson{at}usc.es

We have studied patterns of DNA sequence variation and evolution for 22 genes located on the neo-X and neo-Y chromosomes of Drosophila miranda. As found previously, nucleotide site diversity is greatly reduced on the neo-Y chromosome, with a severely distorted frequency spectrum. There is also an accelerated rate of amino-acid sequence evolution on the neo-Y chromosome. Comparisons of nonsynonymous and silent variation and divergence suggest that amino-acid sequences on the neo-X chromosome are subject to purifying selection, whereas this is much weaker on the neo-Y. The same applies to synonymous variants affecting codon usage. There is also an indication of a recent relaxation of selection on synonymous mutations for genes on other chromosomes. Genes that are weakly expressed on the neo-Y chromosome appear to have a faster rate of accumulation of both nonsynonymous and unpreferred synonymous mutations than genes with high levels of expression, although the rate of accumulation when both types of mutation are pooled is higher for the neo-Y chromosome than for the neo-X chromosome even for highly expressed genes.




This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
D. Bachtrog
Evidence for Male-Driven Evolution in Drosophila
Mol. Biol. Evol., April 1, 2008; 25(4): 617 - 619.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. L. Evans, P. A. Mena, and B. F. McAllister
Positive Selection Near an Inversion Breakpoint on the Neo-X Chromosome of Drosophila americana
Genetics, November 1, 2007; 177(3): 1303 - 1319.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Charlesworth and A. Eyre-Walker
The other side of the nearly neutral theory, evidence of slightly advantageous back-mutations
PNAS, October 23, 2007; 104(43): 16992 - 16997.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
X. Maside and B. Charlesworth
Patterns of Molecular Variation and Evolution in Drosophila americana and Its Relatives
Genetics, August 1, 2007; 176(4): 2293 - 2305.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
L. Loewe and B. Charlesworth
Background Selection in Single Genes May Explain Patterns of Codon Bias
Genetics, March 1, 2007; 175(3): 1381 - 1393.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the Genetics Society of America.