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Originally published as Genetics Published Articles Ahead of Print on October 9, 2006.
Genetics, Vol. 174, 1907-1915, December 2006, Copyright © 2006
doi:10.1534/genetics.106.063453
EMB-4: A Predicted ATPase That Facilitates lin-12 Activity in Caenorhabditis elegans
Iskra Katic*,
and
Iva Greenwald,
,1
* Department of Genetics and Development, Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032
1 Corresponding author: 701 W. 168th St., HHSC 720, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
E-mail: greenwald{at}cancercenter.columbia.edu
The sel-6 gene was previously identified in a screen for suppressors of the egg-laying defect associated with hypermorphic alleles of lin-12 (TAX et al. 1997). Here we show that sel-6 and two other previously defined genes, mal-2 and emb-4, are the same gene, now called "emb-4." We perform a genetic and molecular characterization of emb-4 and show that it functions cell autonomously as a positive regulator of lin-12 activity. Viable alleles identified as suppressors of lin-12 are partial loss-of-function mutations, whereas the null phenotype encompasses a range of lethal terminal phenotypes that apparently are not related to loss of lin-12/Notch signaling. emb-4 encodes a large nuclearly localized protein containing a predicted ATPase domain and has apparent orthologs in fission yeast, plants, and animals.
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Genetics 2006 174: NP.
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