- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.106.060723v1
174/3/1517 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Related articles in Genetics
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Padhukasahasram, B.
- Articles by Nordborg, M.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Padhukasahasram, B.
- Articles by Nordborg, M.
Originally published as Genetics Published Articles Ahead of Print on September 15, 2006.
Genetics, Vol. 174, 1517-1528, November 2006, Copyright © 2006
doi:10.1534/genetics.106.060723
Estimating Recombination Rates From Single-Nucleotide Polymorphisms Using Summary Statistics
Badri Padhukasahasram*,1,
Jeffrey D. Wall*,
Paul Marjoram
and
Magnus Nordborg*
* Molecular and Computational Biology and Biostatistics Division, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089
1 Corresponding author: Biotechnology Building, Room 169, Cornell University, Ithaca, NY 14853.
E-mail: pkbadri{at}yahoo.com
We describe a novel method for jointly estimating crossing-over and gene-conversion rates from population genetic data using summary statistics. The performance of our method was tested on simulated data sets and compared with the composite-likelihood method of R. R. Hudson. For several realistic parameter values, the new method performed similarly to the composite-likelihood approach for estimating crossing-over rates and better when estimating gene-conversion rates. We used our method to analyze a human data set recently genotyped by Perlegen Sciences.
Related articles in Genetics:
Issue Highlights
Genetics 2006 174: NP.
This article has been cited by other articles:
 |
|
 |
|
  J. Yin, M. I. Jordan, and Y. S. Song Joint estimation of gene conversion rates and mean conversion tract lengths from population SNP data Bioinformatics, June 15, 2009; 25(12): i231 - i239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-F. Lefebvre and D. Labuda Fraction of Informative Recombinations: A Heuristic Approach to Analyze Recombination Rates Genetics, April 1, 2008; 178(4): 2069 - 2079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Padhukasahasram, P. Marjoram, J. D. Wall, C. D. Bustamante, and M. Nordborg Exploring Population Genetic Models With Recombination Using Efficient Forward-Time Simulations Genetics, April 1, 2008; 178(4): 2417 - 2427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gay, S. Myers, and G. McVean Estimating Meiotic Gene Conversion Rates From Population Genetic Data Genetics, October 1, 2007; 177(2): 881 - 894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Toleno, P. L. Morrell, and M. T. Clegg Error detection in SNP data by considering the likelihood of recombinational history implied by three-site combinations Bioinformatics, July 15, 2007; 23(14): 1807 - 1814. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Iyengar The Quest for Genes Causing Complex Traits in Ocular Medicine: Successes, Interpretations, and Challenges Arch Ophthalmol, January 1, 2007; 125(1): 11 - 18. [Abstract] [Full Text] [PDF]
|
|
|