- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.106.062018v1
174/3/1469 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Related articles in Genetics
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Hasselmann, M.
- Articles by Beye, M.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Hasselmann, M.
- Articles by Beye, M.
Originally published as Genetics Published Articles Ahead of Print on September 1, 2006.
Genetics, Vol. 174, 1469-1480, November 2006, Copyright © 2006
doi:10.1534/genetics.106.062018
Pronounced Differences of Recombination Activity at the Sex Determination Locus of the Honeybee, a Locus Under Strong Balancing Selection
Martin Hasselmann1 and Martin Beye
Heinrich Heine Universität Düsseldorf, Institut für Genetik, 40225 Düsseldorf, Germany
1 Corresponding author: Institut für Genetik, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
E-mail: martin.hasselmann{at}uni-duesseldorf.de
Recombination decreases the association of linked nucleotide sites and can influence levels of polymorphism in natural populations. When coupled with selection, recombination may relax potential conflict among linked genes, a concept that has played a central role in research on the evolution of recombination. The sex determination locus (SDL) of the honeybee is an informative example for exploring the combined forces of recombination, selection, and linkage on sequence evolution. Balancing selection at SDL is very strong and homozygous individuals at SDL are eliminated by worker bees. The recombination rate is increased up to four times that of the genomewide average in the region surrounding SDL. Analysis of nucleotide diversity (
) reveals a sevenfold increase of polymorphism within the sex determination gene complementary sex determiner (csd) that rapidly declines within 45 kb to levels of genomewide estimates. Although no recombination was observed within SDL, which contains csd, analyses of heterogeneity, shared polymorphic sites, and linkage disequilibrium (LD) show that recombination has contributed to the evolution of the 5' part of some csd sequences. Gene conversion, however, has not obviously contributed to the evolution of csd sequences. The local control of recombination appears to be related to SDL function and mode of selection. The homogenizing force of recombination is reduced within SDL, which preserves allelic differences and specificity, while the increase of recombination activity around SDL relaxes conflict between SDL and linked genes.
Related articles in Genetics:
Issue Highlights
Genetics 2006 174: NP.
This article has been cited by other articles:
![]() |
J. G. de Boer, P. J. Ode, A. K. Rendahl, L. E. M. Vet, J. B. Whitfield, and G. E. Heimpel Experimental Support for Multiple-Locus Complementary Sex Determination in the Parasitoid Cotesia vestalis Genetics, November 1, 2008; 180(3): 1525 - 1535. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. P. Oldroyd, M. H. Allsopp, R. S. Gloag, J. Lim, L. A. Jordan, and M. Beekman Thelytokous Parthenogenesis in Unmated Queen Honeybees (Apis mellifera capensis): Central Fusion and High Recombination Rates Genetics, September 1, 2008; 180(1): 359 - 366. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Hasselmann, X. Vekemans, J. Pflugfelder, N. Koeniger, G. Koeniger, S. Tingek, and M. Beye Evidence for Convergent Nucleotide Evolution and High Allelic Turnover Rates at the complementary sex determiner Gene of Western and Asian Honeybees Mol. Biol. Evol., April 1, 2008; 25(4): 696 - 708. [Abstract] [Full Text] [PDF] |
||||

