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Originally published as Genetics Published Articles Ahead of Print on September 1, 2006.

Genetics, Vol. 174, 1397-1406, November 2006, Copyright © 2006
doi:10.1534/genetics.106.060681

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Perfect Simulation From Nonneutral Population Genetic Models: Variable Population Size and Population Subdivision

Paul Fearnhead1

Department of Mathematics and Statistics, Lancaster University, Lancaster, LA1 4YF, United Kingdom

1 Author e-mail: p.fearnhead{at}lancs.ac.uk

We show how the idea of monotone coupling from the past can produce simple algorithms for simulating samples at a nonneutral locus under a range of demographic models. We specifically consider a biallelic locus and either a general variable population size mode or a general migration model for population subdivision. We investigate the effect of demography on the efficacy of selection and the effect of selection on genetic divergence between populations.






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Copyright © 2006 by the Genetics Society of America.