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Originally published as Genetics Published Articles Ahead of Print on December 30, 2005.
Genetics, Vol. 174, 1365-1371, November 2006, Copyright © 2006
doi:10.1534/genetics.105.051755
Organization of the sex-ratio Meiotic Drive Region in Drosophila simulans
Catherine Montchamp-Moreau1, David Ogereau, Nicole Chaminade, Alexandre Colard and Sylvie Aulard
Laboratoire Populations Génétique et Evolution, CNRS UPR 9034, 91198 Gif-sur-Yvette, France
1 Corresponding author: Laboratoire Populations Génétique et Evolution, CNRS UPR 9034, Ave. de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
E-mail: catherine.montchamp{at}pge.cnrs-gif.fr
Sex-ratio meiotic drive is the preferential transmission of the X chromosome by XY males, which occurs in several Drosophila species and results in female-biased progeny. Although the trait has long been known to exist, its molecular basis remains completely unknown. Here we report a fine-mapping experiment designed to characterize the major drive locus on a sex-ratio X chromosome of Drosophila simulans originating from the Seychelles (XSR6). This primary locus was found to contain two interacting elements at least, both of which are required for drive expression. One of them was genetically tracked to a tandem duplication containing six annotated genes (Trf2, CG32712, CG12125, CG1440, CG12123, org-1), and the other to a candidate region located 
110 kb away and spanning seven annotated genes. RT–PCR showed that all but two of these genes were expressed in the testis of both sex-ratio and standard males. In situ hybridization to polytene chromosomes revealed a complete association of the duplication with the sex-ratio trait in random samples of X chromosomes from Madagascar and Reunion.
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