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Originally published as Genetics Published Articles Ahead of Print on September 15, 2006.
Genetics, Vol. 174, 1229-1236, November 2006, Copyright © 2006
doi:10.1534/genetics.106.061481
Large-Scale Gene Expression Differences Across Brain Regions and Inbred Strains Correlate With a Behavioral Phenotype
Jessica J. Nadler*,
,
Fei Zou
,
,
Hanwen Huang,
Sheryl S. Moy,**,,
Jean Lauder,,,
Jacqueline N. Crawley,,,
David W. Threadgill*,,,
Fred A. Wright,, and
Terry R. Magnuson*,,,1
* Department of Genetics, Carolina Center for Genome Sciences, Department of Biostatistics, ** Department of Psychiatry, Department of Cell and Developmental Biology, Neurodevelopmental Disorders Research Center and North Carolina STAART Center, University of North Carolina, Chapel Hill, North Carolina 27599 and Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland 20892-3730
1 Corresponding author: Department of Genetics, University of North Carolina, CB 7264, 103 Mason Farm Rd., Chapel Hill, NC 27599-7264.
E-mail: trm4{at}med.unc.edu
Behaviors are often highly heritable, polygenic traits. To investigate molecular mediators of behavior, we analyzed gene expression patterns across seven brain regions (amygdala, basal ganglia, cerebellum, frontal cortex, hippocampus, cingulate cortex, and olfactory bulb) of 10 different inbred mouse strains (129S1/SvImJ, A/J, AKR/J, BALB/cByJ, BTBR T+ tf/J, C3H/HeJ, C57BL/6J, C57L/J, DBA/2J, and FVB/NJ). Extensive variation was observed across both strain and brain region. These data provide potential transcriptional intermediates linking polygenic variation to differences in behavior. For example, mice from different strains had variable performance on the rotarod task, which correlated with the expression of >2000 transcripts in the cerebellum. Correlation with this task was also found in the amygdala and hippocampus, but not in other regions examined, indicating the potential complexity of motor coordination. Thus we can begin to identify expression profiles contributing to behavioral phenotypes through variation in gene expression.
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