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Originally published as Genetics Published Articles Ahead of Print on September 1, 2006.
Genetics, Vol. 174, 1151-1159, November 2006, Copyright © 2006
doi:10.1534/genetics.106.060541
Misregulation of Sex-Lethal and Disruption of Male-Specific Lethal Complex Localization in Drosophila Species Hybrids
Manika Pal Bhadra*,1,
Utpal Bhadra
,1 and
James A. Birchler
,2
Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211-7400, * Department of Chemical Biology, Indian Institute of Chemical Technology, Hyderabad 500007, India and Functional Genomics and Gene Silencing Group, Centre for Cellular and Molecular Biology, Hyderabad 500007, India
2 Corresponding author: Division of Biological Sciences, 117 Tucker Hall, University of Missouri, Columbia, MO 65211.
E-mail: birchlerj{at}missouri.edu
A major model system for the study of evolutionary divergence between closely related species has been the unisexual lethality resulting from reciprocal crosses of Drosophila melanogaster and D. simulans. Sex-lethal (Sxl), a critical gene for sex determination, is misregulated in these hybrids. In hybrid males from D. melanogaster mothers, there is an abnormal expression of Sxl and a failure of localization of the male-specific lethal (MSL) complex to the X chromosome, which causes changes in gene expression. Introduction of a Sxl mutation into this hybrid genotype will allow expression of the MSL complex but there is no sequestration to the X chromosome. Lethal hybrid rescue (Lhr), which allows hybrid males from this cross to survive, corrects the SXL and MSL defects. The reciprocal cross of D. simulans mothers by D. melanogaster males exhibits underexpression of Sxl in embryos.
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