- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.106.060004v1
174/2/959 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Valdar, W.
- Articles by Flint, J.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Valdar, W.
- Articles by Flint, J.
Originally published as Genetics Published Articles Ahead of Print on August 3, 2006.
Genetics, Vol. 174, 959-984, October 2006, Copyright © 2006
doi:10.1534/genetics.106.060004
Genetic and Environmental Effects on Complex Traits in Mice
William Valdar*,1,
Leah C. Solberg
,
Dominique Gauguier*,
William O. Cookson*,
J. Nicholas P. Rawlins
,
Richard Mott* and
Jonathan Flint*
* Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom, Medical College of Wisconsin, HMGC, Milwaukee, Wisconsin 53226 and Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, United Kingdom
1 Corresponding author: Wellcome Trust Centre for Human Genetics, Roosevelt Dr., Headington, Oxford OX3 7BN, United Kingdom.
E-mail valdar{at}well.ox.ac.uk
The interaction between genotype and environment is recognized as an important source of experimental variation when complex traits are measured in the mouse, but the magnitude of that interaction has not often been measured. From a study of 2448 genetically heterogeneous mice, we report the heritability of 88 complex traits that include models of human disease (asthma, type 2 diabetes mellitus, obesity, and anxiety) as well as immunological, biochemical, and hematological phenotypes. We show that environmental and physiological covariates are involved in an unexpectedly large number of significant interactions with genetic background. The 15 covariates we examined have a significant effect on behavioral and physiological tests, although they rarely explain >10% of the variation. We found that interaction effects are more frequent and larger than the main effects: half of the interactions explained >20% of the variance and in nine cases exceeded 50%. Our results indicate that assays of gene function using mouse models should take into account interactions between gene and environment.
This article has been cited by other articles:
 |
|
 |
|
  A. Legarra, C. Robert-Granie, E. Manfredi, and J.-M. Elsen Performance of Genomic Selection in Mice Genetics, September 1, 2008; 180(1): 611 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Yazdi, A. K. Sonesson, J. A. Woolliams, and T. H. E. Meuwissen Combined detection and introgression of quantitative trait loci underlying desirable traits J Anim Sci, May 1, 2008; 86(5): 1089 - 1095. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. D. Martinez CD14, Endotoxin, and Asthma Risk: Actions and Interactions Proceedings of the ATS, July 1, 2007; 4(3): 221 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yi, D. Shriner, S. Banerjee, T. Mehta, D. Pomp, and B. S. Yandell An Efficient Bayesian Model Selection Approach for Interacting Quantitative Trait Loci Models With Many Effects Genetics, July 1, 2007; 176(3): 1865 - 1877. [Abstract] [Full Text] [PDF]
|
|