- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.106.058693v1
174/2/915 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Pool, J. E.
- Articles by Aquadro, C. F.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Pool, J. E.
- Articles by Aquadro, C. F.
Originally published as Genetics Published Articles Ahead of Print on September 1, 2006.
Genetics, Vol. 174, 915-929, October 2006, Copyright © 2006
doi:10.1534/genetics.106.058693
History and Structure of Sub-Saharan Populations of Drosophila melanogaster
John E. Pool1 and Charles F. Aquadro
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853
1 Corresponding author: Department of Molecular Biology and Genetics, Biotechnology Bldg., Cornell University, Ithaca, NY 14853.
E-mail: jep36{at}cornell.edu
Drosophila melanogaster is an important model organism in evolutionary genetics, yet little is known about the population structure and the demographic history of this species within sub-Saharan Africa, which is thought to contain its ancestral range. We surveyed nucleotide variation at four 1-kb fragments in 240 individual lines representing 21 sub-Saharan and 4 Palearctic population samples of D. melanogaster. In agreement with recent studies, we find a small but significant level of genetic differentiation within sub-Saharan Africa. A clear geographic pattern is observed, with eastern and western African populations composing two genetically distinct groups. This pattern may have resulted from a relatively recent establishment of D. melanogaster in western Africa. Eastern populations show greater evidence for long-term stability, consistent with the hypothesis that eastern Africa contains the ancestral range of the species. Three sub-Saharan populations show evidence for cosmopolitan introgression. Apart from those cases, the closest relationships between Palearctic and sub-Saharan populations involve a sample from the rift zone (Uganda), suggesting that the progenitors of Palearctic D. melanogaster might have come from this region. Finally, we find a large excess of singleton polymorphisms in the full data set, which is best explained by a combination of population growth and purifying selection.
This article has been cited by other articles:
 |
|
 |
|
  T. Stadler, B. Haubold, C. Merino, W. Stephan, and P. Pfaffelhuber The Impact of Sampling Schemes on the Site Frequency Spectrum in Nonequilibrium Subdivided Populations Genetics, May 1, 2009; 182(1): 205 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Pool and R. Nielsen The Impact of Founder Events on Chromosomal Variability in Multiply Mating Species Mol. Biol. Evol., August 1, 2008; 25(8): 1728 - 1736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Emerson, M. Cardoso-Moreira, J. O. Borevitz, and M. Long Natural Selection Shapes Genome-Wide Patterns of Copy-Number Polymorphism in Drosophila melanogaster Science, June 20, 2008; 320(5883): 1629 - 1631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Chen, P. L. Morrell, M. de la Cruz, and M. T. Clegg Nucleotide Diversity and Linkage Disequilibrium in Wild Avocado (Persea americana Mill.) J. Hered., March 14, 2008; (2008) esn016v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Wong, M. C. Turchin, M. F. Wolfner, and C. F. Aquadro Evidence for Positive Selection on Drosophila melanogaster Seminal Fluid Protease Homologs Mol. Biol. Evol., March 1, 2008; 25(3): 497 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Nolte and C. Schlotterer African Drosophila melanogaster and D. simulans Populations Have Similar Levels of Sequence Variability, Suggesting Comparable Effective Population Sizes Genetics, January 1, 2008; 178(1): 405 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Arunyawat, W. Stephan, and T. Stadler Using Multilocus Sequence Data to Assess Population Structure, Natural Selection, and Linkage Disequilibrium in Wild Tomatoes Mol. Biol. Evol., October 1, 2007; 24(10): 2310 - 2322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hutter, H. Li, S. Beisswanger, D. De Lorenzo, and W. Stephan Distinctly Different Sex Ratios in African and European Populations of Drosophila melanogaster Inferred From Chromosomewide Single Nucleotide Polymorphism Data Genetics, September 1, 2007; 177(1): 469 - 480. [Abstract] [Full Text] [PDF]
|
|