Originally published as Genetics Published Articles Ahead of Print on July 2, 2006.

Genetics, Vol. 174, 541-544, September 2006, Copyright © 2006
doi:10.1534/genetics.106.060863

Genomewide Evolutionary Rates in Laboratory and Wild Yeast

James Ronald^*, Hua Tang and Rachel B. Brem^,1

^* Department of Genome Sciences, University of Washington, Seattle, Washington 98195, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720

¹ Corresponding author: Department of Molecular and Cell Biology, 237 Hildebrand Hall 3206, Berkeley, CA 94720-3206.
E-mail: rbrem{at}berkeley.edu

As wild organisms adapt to the laboratory environment, they become less relevant as biological models. It has been suggested that a commonly used S. cerevisiae strain has rapidly accumulated mutations in the lab. We report a low-to-intermediate rate of protein evolution in this strain relative to wild isolates.

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