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Originally published as Genetics Published Articles Ahead of Print on July 18, 2006.
Genetics, Vol. 174, 525-533, September 2006, Copyright © 2006
doi:10.1534/genetics.106.061705
An Efficient Genetic Screen in Drosophila to Identify Nuclear-Encoded Genes With Mitochondrial Function
T. S. Vivian Liao*,1,
Gerald B. Call
,1,
Preeta Guptan,
Albert Cespedes,
Jamie Marshall,
Kevin Yackle,
Edward Owusu-Ansah,
Sudip Mandal,
Q. Angela Fang,
Gelsey L. Goodstein,
William Kim and
Utpal Banerjee*,,
,2
* Molecular Biology Institute, Department of Molecular, Cell and Developmental Biology and Department of Biological Chemistry, University of California, Los Angeles, California 90095
2 Corresponding author: Department of Molecular, Cell and Developmental Biology, 2204 Life Science, 621 Charles E. Young Dr. South, Los Angeles, CA 90095.
E-mail: banerjee{at}mbi.ucla.edu
We conducted a screen for glossy-eye flies that fail to incorporate BrdU in the third larval instar eye disc but exhibit normal neuronal differentiation and isolated 23 complementation groups of mutants. These same phenotypes were previously seen in mutants for cytochrome c oxidase subunit Va. We have molecularly characterized six complementation groups and, surprisingly, each encodes a mitochondrial protein. Therefore, we believe our screen to be an efficient method for identifying genes with mitochondrial function.
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