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Originally published as Genetics Published Articles Ahead of Print on July 2, 2006.
Genetics, Vol. 174, 519-523, September 2006, Copyright © 2006
doi:10.1534/genetics.106.059311
Accumulation of Recessive Lethal Mutations in Saccharomyces cerevisiae mlh1 Mismatch Repair Mutants Is Not Associated With Gross Chromosomal Rearrangements
Julie Akiko Heck*,
David Gresham
,
David Botstein and
Eric Alani*,1
* Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853 and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544
1 Corresponding author: Department of Molecular Biology and Genetics, Cornell University, 459 Biotechnology Bldg., Ithaca, NY 14853-2703.
E-mail: eea3{at}cornell.edu
We examined mismatch repair (MMR)-defective diploid strains of budding yeast grown for 
160 generations to determine whether decreases in spore viability due to the uncovering of recessive lethal mutations correlated with an increase in gross chromosomal rearrangements (GCRs). No GCRs were detected despite dramatic decreases in spore viability, suggesting that frameshift and/or other unrepaired DNA replication lesions play a greater role than chromosomal instability in decreasing viability in MMR-defective strains.