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Genetics, Vol. 174, 113-123, September 2006, Copyright © 2006
doi:10.1534/genetics.106.060970
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Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York 10029
1 Corresponding author: Mount Sinai School of Medicine, 1425 Madison Ave., Room 15-70, New York, New York 10029.
E-mail: matthew.oconnell{at}mssm.edu
cells. Cdr1 encodes a protein kinase previously identified as a negative regulator of Wee1 activity in response to limited nutrition, but Cdr1 has not previously been linked to checkpoint signaling. Overproduction of Cdr1 promotes checkpoint defects and exacerbates the defective response to DNA damage of cells lacking Chk1. We conclude that regulation of Wee1 by Cdr1 and possibly by related kinases is an important antagonist of Chk1 signaling and represents a novel negative regulation of cell cycle arrest promoted by this checkpoint. This article has been cited by other articles:
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